Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2.
Identifieur interne : 003627 ( Main/Exploration ); précédent : 003626; suivant : 003628Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2.
Auteurs : Deyan Luo [République populaire de Chine] ; Bing Ni ; Guangyu Zhao ; Zhengcai Jia ; Lili Zhou ; Marek Pacal ; Liangyan Zhang ; Songle Zhang ; Li Xing ; Zhihua Lin ; Li Wang ; Jintao Li ; Yunfei Liang ; Xinfu Shi ; Tingting Zhao ; Liyun Zou ; Yuzhang Wu ; Xiliang WangSource :
- Viral immunology [ 0882-8245 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (usage thérapeutique), Cricetinae, Cricetulus, Equus caballus (immunologie), Femelle, Fragments Fab d'immunoglobuline (usage thérapeutique), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Tests de neutralisation, Virus du SRAS (isolement et purification).
- MESH :
- anatomopathologie : Poumon.
- immunologie : Equus caballus, Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- usage thérapeutique : Anticorps antiviraux, Fragments Fab d'immunoglobuline.
- virologie : Poumon.
- Animaux, Cricetinae, Cricetulus, Femelle, Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (therapeutic use), Cricetinae, Cricetulus, Disease Models, Animal, Female, Horses (immunology), Immunoglobulin Fab Fragments (therapeutic use), Lung (pathology), Lung (virology), Neutralization Tests, SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control).
- MESH :
- chemical , therapeutic use : Antibodies, Viral, Immunoglobulin Fab Fragments.
- immunology : Horses, Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- pathology : Lung.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Lung.
- Animals, Cricetinae, Cricetulus, Disease Models, Animal, Female, Neutralization Tests.
Abstract
To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectively and sustain high levels for 1 wk in animal lungs. All animals were protected from SARS-CoV infection in preventive settings. Further, when used therapeutically this antibody led to an approximately 4-log(10) decrease in viral burden in infected animal lungs. The pathological changes in lungs correlated closely with the dose of antibody administered. The excellent preventive and therapeutic roles of equine anti-SARS-CoV F(ab')(2) in several animal models, including the novel Chinese hamster model described in this study, have provided exciting data concerning its potential clinical study.
DOI: 10.1089/vim.2007.0038
PubMed: 17931120
Affiliations:
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Ni</name></author><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name></author><author><name sortKey="Jia, Zhengcai" sort="Jia, Zhengcai" uniqKey="Jia Z" first="Zhengcai" last="Jia">Zhengcai Jia</name></author><author><name sortKey="Zhou, Lili" sort="Zhou, Lili" uniqKey="Zhou L" first="Lili" last="Zhou">Lili Zhou</name></author><author><name sortKey="Pacal, Marek" sort="Pacal, Marek" uniqKey="Pacal M" first="Marek" last="Pacal">Marek Pacal</name></author><author><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name></author><author><name sortKey="Zhang, Songle" sort="Zhang, Songle" uniqKey="Zhang S" first="Songle" last="Zhang">Songle Zhang</name></author><author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name></author><author><name sortKey="Lin, Zhihua" sort="Lin, Zhihua" uniqKey="Lin Z" first="Zhihua" last="Lin">Zhihua Lin</name></author><author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name></author><author><name sortKey="Li, Jintao" sort="Li, Jintao" uniqKey="Li J" first="Jintao" last="Li">Jintao Li</name></author><author><name sortKey="Liang, Yunfei" sort="Liang, Yunfei" uniqKey="Liang Y" first="Yunfei" last="Liang">Yunfei Liang</name></author><author><name sortKey="Shi, Xinfu" sort="Shi, Xinfu" uniqKey="Shi X" first="Xinfu" last="Shi">Xinfu Shi</name></author><author><name sortKey="Zhao, Tingting" sort="Zhao, Tingting" uniqKey="Zhao T" first="Tingting" last="Zhao">Tingting Zhao</name></author><author><name sortKey="Zou, Liyun" sort="Zou, Liyun" uniqKey="Zou L" first="Liyun" last="Zou">Liyun Zou</name></author><author><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name></author><author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name></author></analytic><series><title level="j">Viral immunology</title><idno type="ISSN">0882-8245</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (therapeutic use)</term><term>Cricetinae</term><term>Cricetulus</term><term>Disease Models, Animal</term><term>Female</term><term>Horses (immunology)</term><term>Immunoglobulin Fab Fragments (therapeutic use)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Neutralization Tests</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (usage 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Animal</term><term>Female</term><term>Neutralization Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cricetinae</term><term>Cricetulus</term><term>Femelle</term><term>Modèles animaux de maladie humaine</term><term>Syndrome respiratoire aigu sévère</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectively and sustain high levels for 1 wk in animal lungs. All animals were protected from SARS-CoV infection in preventive settings. Further, when used therapeutically this antibody led to an approximately 4-log(10) decrease in viral burden in infected animal lungs. The pathological changes in lungs correlated closely with the dose of antibody administered. The excellent preventive and therapeutic roles of equine anti-SARS-CoV F(ab')(2) in several animal models, including the novel Chinese hamster model described in this study, have provided exciting data concerning its potential clinical study.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Jia, Zhengcai" sort="Jia, Zhengcai" uniqKey="Jia Z" first="Zhengcai" last="Jia">Zhengcai Jia</name><name sortKey="Li, Jintao" sort="Li, Jintao" uniqKey="Li J" first="Jintao" last="Li">Jintao Li</name><name sortKey="Liang, Yunfei" sort="Liang, Yunfei" uniqKey="Liang Y" first="Yunfei" last="Liang">Yunfei Liang</name><name sortKey="Lin, Zhihua" sort="Lin, Zhihua" uniqKey="Lin Z" first="Zhihua" last="Lin">Zhihua Lin</name><name sortKey="Ni, Bing" sort="Ni, Bing" uniqKey="Ni B" first="Bing" last="Ni">Bing Ni</name><name sortKey="Pacal, Marek" sort="Pacal, Marek" uniqKey="Pacal M" first="Marek" last="Pacal">Marek Pacal</name><name sortKey="Shi, Xinfu" sort="Shi, Xinfu" uniqKey="Shi X" first="Xinfu" last="Shi">Xinfu Shi</name><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><name sortKey="Zhang, Songle" sort="Zhang, Songle" uniqKey="Zhang S" first="Songle" last="Zhang">Songle Zhang</name><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><name sortKey="Zhao, Tingting" sort="Zhao, Tingting" uniqKey="Zhao T" first="Tingting" last="Zhao">Tingting Zhao</name><name sortKey="Zhou, Lili" sort="Zhou, Lili" uniqKey="Zhou L" first="Lili" last="Zhou">Lili Zhou</name><name sortKey="Zou, Liyun" sort="Zou, Liyun" uniqKey="Zou L" first="Liyun" last="Zou">Liyun Zou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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